The Antidote, first appearing in Pokémon Red, Blue and Yellow Gameboy games and appearing in every game ever since, is a one-time-use item that cures the Pokémon it is used on of poisoning. It must be used by the trainer, as it is a man-made item. If given to a Pokémon to hold, they will not be able to use it if poisoned because it is man-made. Another item with a similar effect is the Pecha Berry, which can be held by a Pokémon to cure poisoning automatically.
 In-Game Descriptions
- Gold/Silver/Crystal: Cures poisoned Pokémon.
- Ruby/Sapphire/Emerald: Heals a poisoned Pokémon.
- FireRed/LeafGreen: A spray-type medicine. It heals one Pokémon from a poisoning.
- Diamond/Pearl/Platinum: A spray-type medicine. It lifts the effect of poison from one Pokémon.
- HeartGold/SoulSilver: A spray-type medicine. It lifts the effect of poison from one Pokémon.
- Black/White: A spray-type medicine. It lifts the effect of poison from one Pokémon.
 How To Obtain
• This item can be bought in shops in-game on all generations and game cartridges.
• This item can be traded between all games, provided the Pokémon being traded is holding the Antidote as its item and both game cartridges can trade back and forth.
In all games, you can buy Antidotes at nearly any Pokémart for $100. They can also sometimes be found as items in Pokéballs on the ground of buildings, routes, and caves.
From Generation III onward, an Antidote is an item that can be picked up at random by a Pokémon that has the Pickup Ability, which finds items at random after a battle, but the user of the Pickup Ability cannot be holding an item or else the Ability won't work.