A Nuzlocke challenge is an advanced way to play Pokémon. It was created when a comic maker decided to make his playthrough of Pokémon Ruby more interesting. Since then, multiple people have done Nuzlocke runs and made comics. Nuzlocke is a combination of Nuzleaf (Pokémon) and John Locke (LOST). There are only two standard Nuzlocke rules, but there are plenty of other things to add to make it even harder. Monotype challenges are quite similar.
The two main rules of Nuzlockes are quite simple: 1. If a Pokémon faints it is dead and must be released. 2. You may only catch the first Pokémon on each route.
Other difficulties would be No Healing in Battle and other things.
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