Series 4: Best Wishes Series
The Best Wishes Series is the fourth series of the Pokemon anime. Following the events of the Diamond and Pearl series, a new adventure for Ash and Pikachu begins, as they head to the Unova region. He arrives with Professor Oak and his mother, Delia Ketchum, and they are introduced to the Unova region by Professor Juniper, who takes them to the lab. Ash and Pikachu encounter a legendary Pokémon: Zekrom who briefly appears and mysteriously confuses the town residents. After spending time in Unova, Ash eventually decides to remain in the region to begin his new journey for the Unova League.
Ash travels throughout the Unova region with Iris, whose goal is to become a Dragon Master. After his first Gym Battle, Cilan joins the group as well. Cilan's goal is to become a Top Pokemon Connoisseur. Ash encounters Trip as well, a photographer and who would eventually become his new rival.
Team Rocket makes a return in new uniforms, having been sent to Unova on a special mission by Giovanni. Although, they trio returns to their original white uniforms later into the series.
Ash successfully collected eight Gym Badges and participated in the Unova League's Vertress Conference, where he finished in the Top 8.
After competing in the league, Professor Juniper offered Ash, Iris and Cilan to head to the White Ruins to possibly learn more about Reshiram, after hearing that her father discovered something new in the area. Ash, Iris, and Cilan encounter Team Plasma numerous times during their trip to the ruins. During the final encounter, Ghetsis successfully resurrected Reshiram, but Ash and his friends, with the help of Looker, N, Anthea, Concordia, and Team Rocket, managed to stop the evil organization from gaining complete control over Reshiram.
Finally, Ash, Iris and Cilan decide to head to Kanto, stopping by the Decolore Islands along the way. After going through the islands, the group arrives in Kanto. Iris and Cilan both decide to head to Johto. The group head to Vermillion City, where Iris and Cilan would take the train heading to the Johto region. Ash says his goodbyes as he separates from Iris and Cilan, and he and Alexa continues on to Pallet Town.
After spending time in Pallet Town and seeing the new Pokemon from Alexa, he decides to head to the Kalos region. The series conclude with Ash saying goodbye to Professor Oak and his mother, Delia Ketchum, as heads on the plane, bound for the Kalos region, leading to the XY Series.
The American dubbed version is known as Pokémon Black and White and marks the return of the Who's That Pokémon? The American dub is split into three seasons:
- Pokemon: Black and White
- Pokemon Black and White Rival Destinies
- Pokemon Black and White Adventures in Unova (and Beyond)
 Pokemon Black and White
- BW001 In the Shadow of Zekrom!
- BW002 Enter Iris and Axew!
- BW003 A Sandile Gusher of Change!
- BW004 The Battle Club and Tepig's Choice!
- BW005 Triple Leaders, Team Threats!
- BW006 Dreams By the Yard Full
- BW007 Snivy Plays Hard to Catch!
- BW008 Saving Darmanitan From the Bell
- BW009 The Bloom Is on Axew!
- BW010 A Rival Battle for Club Champ!
- BW011 A Home For Dwebble!
- BW012 Here Comes The Trubbish Squad
- BW013 Mincinno-Neat and Tidy
- BW014 A Night in the Nacrene City Museum!
- BW015 The Battle According to Lenora
- BW016 Rematch at the Nacrene Gym
- BW017 Scraggy-Hatched to Be Wild
- BW018 Seawaddle and Burgh in Pinwheel Forest
- BW019 A Connoisseur's Revenge!]
- BW020 Dancing With the Ducklett Trio!
- BW021 The Lost World of Gothitelle!
- BW022 A Venipede Stampede
- BW023 Battling For The Love of Bug-Types!
- BW024 Emolga the Irresistible!
- BW025 Emolga and the New Volt Switch!
- BW026 Scare at the Litwick Mansion!
- BW027 The Dragon Master's Path!
- BW028 Oshawott's Lost Scalchop!
- BW029 Cottonee in Love!
- BW030 A UFO for Elgyem!
- BW031 Ash and Trip's Third Battle!
- BW032 Facing Fear With Eyes Wide Open!
- BW033 Iris and Excadrill Against the Dragon Buster
- BW034 Gotta Catch a Roggenrola!
- BW035 Where Did You Go, Audino?
- BW036 Archops In The Modern World
- BW037 A Fishing Connoisseur in a Fishy Competition!
- BW038 Movie Time! Zorua in "The Legend of the Pokémon Knight"!
- BW039 Reunion Battles In Nimbasa!
- BW040 Cilan Versus Trip, Ash Versus Georgia!
- BW041 The Club Battle Hearts of Fury: Emolga Versus Sawk!
- BW042 Club Battle Finale: A Hero's Outcome!
- BW043 Meowth's Scrafty Tactics!
- BW044 Purrloin: Sweet or Sneaky?
- BW045 Beheeyem, Duosion, and the Dream Thief!
- BW046 The Beartic Mountain Feud!
- BW047 Crisis from the Underground Up!
- BW048 Battle for the Underground!
 Pokemon Black and White: Rival Destinies
- BW049 Enter Elesa, Electrifying Gym Leader!
- BW050 Dazzling the Nimbasa Gym!
- BW051 Lost at the Stamp Rally!
- BW052 Ash Versus the Champion!
- BW053 A Maractus Musical!
- BW054 The Four Seasons of Sawsbuck!
- BW055 Scraggy and the Demanding Gothita!
- BW056 The Lonely Deino!
- BW057 The Mighty Accelguard to the Rescue!
- BW058 A Call for Brotherly Love!
- BW059 Stopping the Rage of Legends! (Part 1)
- BW060 Stopping the Rage of Legends! (Part 2)
- BW061 Battling the King of the Mines!
- BW062 Crisis at Chargestone Cave!
- BW063 Evolution Exchange Excitement!
- BW064 Explorers of the Hero's Ruin!
- BW065 Battling the Bully!
- BW066 Baffling the Bouffalant!
- BW067 Cilan Takes Flight!
- BW068 An Amazing Aerial Battle!
- BW069 Climbing the Tower of Success!
- BW070 The Clubsplosion Begins!
- BW071 Search for the Clubultimate!
- BW072 A Clubsplosion of Excitement!
- BW073 Commanding the Clubsposion Crown!
- BW074 Battling the Leaf Thieves!
- BW075 A Restoration Confrontation! Part 1
- BW076 A Restoration Confrontation! Part 2
- BW077 Evolution by Fire!
- BW078 Guarding the Guardian of the Mountain!
- BW079 Caution: Icy Battle Conditions!
- BW080 Clash of the Connoisseurs!
- BW081 Crisis at Ferroseed Research!
- BW082 An Epic Defense Force!
- BW083 Rocking the Virbank Gym! Part 1
- BW084 Rocking the Virbank Gym! Part 2
- BW085 All for the Love of Meloetta!
- BW086 Piplup, Pansage, and a Meeting of the Times!
- BW087 Expedition to Onix Island!
- BW088 The Mystery of the Missing Cubchoo!
- BW089 Iris and the Rogue Dragonite!
- BW090 Jostling for the Junior Cup!
- BW091 Battling Authority Once Again!
- BW092 Ash, Iris and Trip: Then There Were Three!
- BW093 Goodbye, Junior Cup - Hello Adventure!
- BW094 The Road to Humilau
- BW095 Unrest at the Nursery!
- BW096 Meloetta and the Undersea Temple!
- BW097 Unova's Survival Crisis!
 Pokemon Black and White: Adventures in Unova
- BW098 Beauties Battling for Pride and Prestige!
- BW099 A Surface to Air Tag Battle Team!
- BW100 A Village Homecoming!
- BW101 Drayden Versus Iris: Past, Present, and Future!
- BW102 Team Eevee and the Pokemon Resue Squad!
- BW103 Curtain Up, Unova League!
- BW104 Mission: Defeat Your Rival!
- BW105 Lost at the League!
- BW106 Strong Strategy Steals the Show!
- BW107 Cameron's Secret Weapon!
- BW108 A Unova League Evolution!
- BW109 New Places...Familiar Faces!
- BW110 The Name's N!
- BW111 There's a New Gym Leader in Town!
- BW112 Team Plasma's Pokemon Power Plot!
- BW113 The Light of Floccesy Ranch!
- BW114 Saving Braviary
- BW115 The Pokemon Harbor Patrol!
- BW116 Fires of a Red-Hot Reunion!
- BW117 Team Plasma's Pokemon Manipulation
- BW118 Secrets From Out of the Fog!
- BW119 Meowth, Colress, and Team Rivalry!
- BW120 Ash and N: A Clash of Ideals!
- BW121 Team Plasma and the Awakening Ceremony!
- BW122 What Lies Beyond Truth And Ideals!
 Pokemon Black and White: Adventures in Unova and Beyond
- BW123 Farewell, Unova! Setting Sail for New Adventures!
- BW124 Danger, Sweet as Honey!
- BW125 Cilan and the Case of the Purrloin Witness!
- BW126 Crowning the Scalchop King!
- BW127 The Island of Illusions!
- BW128 To Catch a Rotom!
- BW129 The Pirates of Decolore!
- BW130 Butterfree and Me!
- BW131 The Path That Leads to Goodbye!
- BW132 Searching for a Wish!
- BW133 Capacia Island UFO!
- BW134 The Journalist from Another Region!
- BW135 Mystery on a Deserted Island!
- BW136 A Pokemon of a Different Color!
- BW137 Celebrating the Hero's Comet!
- BW138 Go, Go Gogoat!
- BW139 Team Rocket's Shocking Recruit!
- BW140 Survival of the Striaton Gym!
- BW141 Best Wishes Until We Meet Again!
- BW142 The Dream Continues! (final episode of the Best Wishes series)
- 14 Pokemon the Movie: White-Victini and Zekrom / Black-Victini and Reshiram
- 15 Pokemon: Kyurem VS The Sword of Justice
- 16 Pokemon: Genesect and the Legend Awakened
- Ash receives a new outfit once again.
- This is the first time that Ash regresses in a Pokemon League, only reaching the Top 8 in the Unova League, as opposed to the Top 4 in the Sinnoh League.
- Team Rocket obtain new outfits, although they switch back to their original outfits.
- This is the second series that the current English voice actors of TPCI has dubbed. As of the completion of this series, the current voice actors have dubbed more series' than the original 4Kids voice actors.